Illustration of the generic residue numbering system on the topological structure of one repeat in Nav or Cav channels.
2024.12.11

An invariant residue, represented as pink circle, in the middle of each of the S1-S6 and P1-SF-P2 segments, is selected as the benchmark in the generic numbering system and numbered 30.

The benchmark is selected as the most conserved residue in the middle of a structural segment and assigned the residue number 30 to ensure that all residues would have a positive number. The term "identifier" refers to the structural position relative to the benchmark residue, depicted as the following: the one-letter code for an amino acid is followed with, in subscript, the segment number and repeat number, a comma, and the residue number relative to the benchmark residue.

https://www.sciencedirect.com/science/article/pii/S2451945624003106?via%3Dihub

Table1_disease mutation.zip