Publications
Publications
2024
2023
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2021
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2005
2004
2003
2024
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
CryoSeek II: Cryo-EM analysis of glycofibrils from freshwater reveals well-structured glycans coating linear tetrapeptide repeats
Tongtong Wang#, Wenze Huang#, Kui Xu, Yitong Sun, Qiangfeng Cliff Zhang, Chuangye Yan*, Zhangqiang Li*, Nieng Yan*
Proc Natl Acad Sci U S A. 10.1073/pnas.2423943122. 2024 Dec 31
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Drug discovery targeting Nav1.8: Structural insights and therapeutic potential
Huan Wang#, Jian Huang, Jie Zang, Xueqin Jin*, Nieng Yan*
Curr Opin Chem Biol. 10.1016/j.cbpa.2024.102538. 2024 Dec
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
CryoSeek: A strategy for bioentity discovery using cryoelectron microscopy
Tongtong Wang#, Zhangqiang Li#*, Kui Xu, Wenze Huang, Gaoxingyu Huang, Qiangfeng Cliff Zhang, Nieng Yan*
Proc Natl Acad Sci U S A. 10.1073/pnas.2417046121. 2024 Oct 15
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
A versatile residue numbering scheme for Nav and Cav channels
Xueqin Jin#*, Jian Huang#*, Huan Wang#, Kan Wang, Nieng Yan*
Cell Chem Biol. 10.1016/j.chembiol.2024.07.008. 2024 Aug 15
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for human Cav3.2 inhibition by selective antagonists
Jian Huang#, Xiao Fan#*, Xueqin Jin#, Chen Lyu, Qinmeng Guo, Tao Liu, Jiaofeng Chen, Amaël Davakan, Philippe Lory, Nieng Yan*
Cell Res. 10.1038/s41422-024-00959-8. 2024 Apr 11.
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure-guided discovery of protein and glycan components in native mastigonemes
Junhao Huang#, Hui Tao#, Jikun Chen#, Yang Shen, Jianlin Lei, Junmin Pan*, Chuangye Yan*, Nieng Yan*
Cell. 187(7):1733-1744.e12. 10.1016/j.cell.2024.02.037. 2024 Mar 28
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels
Zhangqiang Li#*, Ye Cong#, Tong Wu#, Tongtong Wang#, Xinyao Lou, Xinyu Yang, Nieng Yan*
Cell Res. 10.1038/s41422-024-00940-5 2024 Mar 5
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Dissection of the structure–function relationship of Nav channels
Zhangqiang Li#*, Qiurong Wu#, Gaoxingyu Huang#, Xueqin Jin#, Jiaao Li, Xiaojing Pan, Nieng Yan*
Proc Natl Acad Sci U S A. 121(9):e2322899121. 10.1073/pnas.2322899121. 2024 Feb 27
2023
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural biology of voltage-gated calcium channels
Xia Yao#*, Shuai Gao#*, Nieng Yan*
Channels (Austin). 18(1):2290807. 10.1080/19336950.2023.2290807. 2023 Dec 7
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
A structural atlas of druggable sites on Nav channels
Zhangqiang Li#*, Qiurong Wu#, Nieng Yan*
Channels (Austin). 18(1):2287832. 10.1080/19336950.2023.2287832. 2023 Nov 30
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine
Shuai Gao#*, Xia Yao#, Jiaofeng Chen#, Gaoxingyu Huang#, Xiao Fan#, Lingfeng Xue#, Zhangqiang Li, Tong Wu, Yupeng Zheng, Jian Huang, Xueqin Jin, Yan Wang, Zhifei Wang, Yong Yu, Lei Liu, Xiaojing Pan, Chen Song*, Nieng Yan*
Cell. 186(24):5363-5374.e16. 10.1016/j.cell.2023.10.007. 2023 Nov 22
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Dual-pocket inhibition of Nav channels by the antiepileptic drug lamotrigine
Jian Huang#, Xiao Fan#*, Xueqin Jin, Liming Teng, Nieng Yan*
Proc Natl Acad Sci U S A. 120(41):e2309773120. 10.1073/pnas.2309773120. 2023 Oct 10
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Cannabidiol inhibits Nav channels through two distinct binding sites
Jian Huang#, Xiao Fan#, Xueqin Jin, Sooyeon Jo, Hanxiong Bear Zhang, Akie Fujita, Bruce P Bean*, Nieng Yan*
Nat Commun. 14(1):3613. 10.1038/s41467-023-39307-6. 2023 Jun 17
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural mapping of Nav1.7 antagonists
Qiurong Wu#, Jian Huang#*, Xiao Fan#*, Kan Wang#, Xueqin Jin #, Gaoxingyu Huang, Jiaao Li, Xiaojing Pan*, Nieng Yan*
Nat Commun. 14(1):3224. 10.1038/s41467-023-38942-3. 2023 Jun 3
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Cryo-EM structure supports a role of AQP7 as a junction protein
Peng Huang, Raminta Venskutonytė, Rashmi B. Prasad, Hamidreza Ardalani, Sofia W. de Maré, Xiao Fan, Ping Li, Peter Spégel, Nieng Yan, Pontus Gourdon, Isabella Artner, Karin Lindkvist-Petersson
Nat Commun. 14(1):600. 10.1038/s41467-023-36272-y. 2023 Feb 3
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Cryo-EM structure of human voltage-gated sodium channel Nav1.6
Xiao Fan#*, Jian Huang#, Xueqin Jin, Nieng Yan*
Proc Natl Acad Sci U S A. 120(5):e2220578120. 10.1073/pnas.2220578120. 2023 Jan 31
2022
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels.
Xia Yao#, Shuai Gao#*, Jixin Wang#, Zhangqiang Li#, Jian Huang, Yan Wang, Zhifei Wang, Jiaofeng Chen, Xiao Fan, Weipeng Wang, Xueqin Jin, Xiaojing Pan, Yong Yu, Armando Lagrutta, Nieng Yan*
Cell. 185(25):4801-4810.e13. 10.1016/j.cell.2022.10.024. 2022 Dec 8
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect
Xin Jiang#, Nieng Yan, Dong Deng*, Chuangye Yan*
IUBMB Life. 74(12):1180-1199. 10.1002/iub.2668. 2022 Dec
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments
Xia Yao#, Yan Wang, Zhifei Wang, Xiao Fan, Di Wu, Jian Huang, Alexander Mueller, Sarah Gao, Miaohui Hu, Carol V Robinson, Yong Yu, Shuai Gao*, Nieng Yan*
Nat Commun. 13(1):7358. 10.1038/s41467-022-35026-6. 2022 Nov 30
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for pore blockade of human voltage-gated calcium channel Cav1.3 by motion sickness drug cinnarizine
Xia Yao#*, Shuai Gao#, Nieng Yan*
Cell Res. 32(10):946-948. 10.1038/s41422-022-00663-5. 2022 Oct
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Nav1.7
Gaoxingyu Huang#, Qiurong Wu#, Zhangqiang Li#, Xueqin Jin#, Xiaoshuang Huang, Tong Wu, Xiaojing Pan*, Nieng Yan*
Proc Natl Acad Sci U S A. 119(33): e2209164119. 10.1073/pnas.2209164119. 2022 Aug 16
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8
Xiaoshuang Huang#, Xueqin Jin#, Gaoxingyu Huang#, Jian Huang, Tong Wu, Zhangqiang Li, Jiaofeng Chen, Fang Kong, Xiaojing Pan*, Nieng Yan*
Proc Natl Acad Sci U S A.119(30):e2208211119. 10.1073/pnas.2208211119. 2022 Jul 26
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
The next decade of protein structure
Corinne A Lutomski, Tarick J El-Baba, Carol V Robinson, Roland Riek, Sjors H W Scheres, Nieng Yan, Mohammed AlQuraishi, Lu Gan
Cell. 185(15):2617-2620. 10.1016/j.cell.2022.06.011. 2022 Jul 21
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Cryo-EM structure of human glucose transporter GLUT4
Yafei Yuan#, Fang Kong#, Hanwen Xu, Angqi Zhu, Nieng Yan*, Chuangye Yan*
Nat Commun. 13(1):2671.  10.1038/s41467-022-30235-5. 2022 May 13
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular basis for inhibiting human glucose transporters by exofacial inhibitors
Nan Wang#, Shuo Zhang, Yafei Yuan, Hanwen Xu, Elisabeth Defossa, Hans Matter, Melissa Besenius, Volker Derdau, Matthias Dreyer, Nis Halland, Kaihui Hu He, Stefan Petry, Michael Podeschwa, Norbert Tennagels, Xin Jiang*, Nieng Yan*
Nat Commun. 13(1):2632. 10.1038/s41467-022-30326-3. 2022 May 12
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
Gaoxingyu Huang#, Dongliang Liu#, Weipeng Wang#, Qiurong Wu, Jiaofeng Chen, Xiaojing Pan, Huaizong Shen*, Nieng Yan*
Cell Rep. 39(4):110735. 10.1016/j.celrep.2022.110735. 2022 Apr 26
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural advances of sterol sensing domain-containing proteins
Xuelan Wu#, Renhong Yan, Pingping Cao, Hongwu Qian*, Nieng Yan*
Trends Biochem Sci. 47(4):289-300. 10.1016/j.tibs.2021.12.005. 2022 Apr
2021
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of human Cav2.2 channel blocked by the painkiller ziconotide
Shuai Gao#, Xia Yao#, Nieng Yan*
Nature. 596(7870):143-147. 10.1038/s41586-021-03699-6. 2021 Aug
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for sterol sensing by Scap and Insig
Renhong Yan#*, Pingping Cao#, Wenqi Song#, Yaning Li#, Tongtong Wang, Hongwu Qian, Chuangye Yan*, Nieng Yan*
Cell Rep. 35(13):109299. 10.1016/j.celrep.2021.109299. 2021 Jun 29
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural Basis for the Modulation of Ryanodine Receptors
Deshun Gong*, Nieng Yan*, Hannah A Ledford*
Trends Biochem Sci. 46(6):489-501. 10.1016/j.tibs.2020.11.009. 2021 Jun
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Atomistic Details of Charge/Space Competition in the Ca2+ Selectivity of Ryanodine Receptors
Chunhong Liu, Aihua Zhang, Nieng Yan, Chen Song*
J Phys Chem Lett. 12(17):4286-4291. 10.1021/acs.jpclett.1c00681. 2021 May 6
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine*
Zhangqiang Li#*, Xueqin Jin#, Tong Wu#, Gaoxingyu Huang#, Kun Wu, Jianlin Lei, Xiaojing Pan, Nieng Yan*
Angew Chem Int Ed Engl. 60(20):11474-11480. 10.1002/anie.202102196. 2021 May 10
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies
Xiaojing Pan#*, Zhangqiang Li#, Xueqin Jin#, Yanyu Zhao#, Gaoxingyu Huang#, Xiaoshuang Huang, Zilin Shen, Yong Cao, Mengqiu Dong, Jianlin Lei, Nieng Yan*
Proc Natl Acad Sci U S A. 118(11): e2100066118. 10.1073/pnas.2100066118. 2021 Mar 16
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome
Zhangqiang Li#, Xueqin Jin, Tong Wu, Xin Zhao, Weipeng Wang, Jianlin Lei, Xiaojing Pan*, Nieng Yan*
Proc Natl Acad Sci U S A. 118(11): e2100069118. 10.1073/pnas.2100069118. 2021 Mar 16
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols
Renhong Yan#, Pingping Cao#, Wenqi Song#, Hongwu Qian, Ximing Du, Hudson W Coates, Xin Zhao, Yaning Li, Shuai Gao, Xin Gong, Ximing Liu, Jianhua Sui, Jianlin Lei, Hongyuan Yang, Andrew J Brown, Qiang Zhou, Chuangye Yan*, Nieng Yan*
Science, 371(6533): eabb2224. 10.1126/science.abb2224. 2021 Mar 5
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Cav1.1 by Dihydropyridine Compounds*
Shuai Gao*, Nieng Yan*
Angew Chem Int Ed Engl. 60(6):3131-3137. 10.1002/anie.202011793. 2021 Feb 8
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents
Jian Huang#, Yafei Yuan#, Na Zhao#, Debing Pu, Qingxuan Tang, Shuo Zhang, Shuchen Luo, Xikang Yang, Nan Wang, Yu Xiao, Tuan Zhang, Zhuoyi Liu, Tomoyo Sakata-Kato, Xin Jiang*, Nobutaka Kato*, Nieng Yan*, Hang Yin*
Proc Natl Acad Sci U S A. 118(3):e2017749118. 10.1073/pnas.2017749118. 2021 Jan 19
2020
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural and functional diversity calls for a new classification of ABC transporters
Christoph Thomas*, Stephen G. Aller, Konstantinos Beis, Elisabeth P. Carpenter, Geoffrey Chang, Lei Chen, Elie Dassa, Michael Dean, Franck Duong Van Hoa, Damian Ekiert, Robert Ford, Rachelle Gaudet, Xin Gong, I. Barry Holland, Yihua Huang, Daniel K. Kahne, Hiroaki Kato, Vassilis Koronakis, Christopher M. Koth, Youngsook Lee, Oded Lewinson, Roland Lill, Enrico Martinoia, Satoshi Murakami, Heather W. Pinkett, Bert Poolman, Daniel Rosenbaum, Balazs Sarkadi, Lutz Schmitt, Erwin Schneider, Yigong Shi, Show-Ling Shyng, Dirk J. Slotboom, Emad Tajkhorshid, D. Peter Tieleman, Kazumitsu Ueda, András Váradi, Po-Chao Wen, Nieng Yan, Peng Zhang, Hongjin Zheng, Jochen Zimmer, Robert Tampé*
FEBS Lett. 594(23):3767-3775. 10.1002/1873-3468.13935. 2020 Dec
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis of ion transport and inhibition in ferroportin
Yaping Pan#*, Zhenning Ren#, Shuai Gao#*, Jiemin Shen#, Lie Wang, Zhichun Xu, Ye Yu, Preetham Bachina, Hanzhi Zhang, Xiao Fan, Arthur Laganowsky, Nieng Yan, Ming Zhou*
Nat Commun. 11(1):5686. 10.1038/s41467-020-19458-6. 2020 Nov 10
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum
Xin Jiang#, Yafei Yuan#, Jian Huang#, Shuo Zhang#, Shuchen Luo, Nan Wang, Debing Pu, Na Zhao, Qingxuan Tang, Kunio Hirata, Xikang Yang, Yaqing Jiao, Tomoyo Sakata-Kato, Jia-Wei Wu, Chuangye Yan, Nobutaka Kato, Hang Yin*, Nieng Yan*
Cell. 183(1):258-268.e12. 10.1016/j.cell.2020.08.015. 2020 Oct 1
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Cryo-EM analysis of a membrane protein embedded in the liposome
Xia Yao#, Xiao Fan#*, Nieng Yan*
Proc Natl Acad Sci U S A. 117(31):18497-18503. 10.1073/pnas.2009385117. 2020 Aug 4
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2
Hongwu Qian#, Xuelan Wu#, Ximing Du#, Xia Yao, Xin Zhao, Joyce Lee, Hongyuan Yang*, Nieng Yan*
Cell. 182(1):98-111. 10.1016/j.cell.2020.05.020. 2020 Jul 9
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc
Shuai Gao#, William C Valinsky, Nguyen Cam On, Patrick R Houlihan, Qian Qu, Lei Liu, Xiaojing Pan, David E Clapham, Nieng Yan*
Proc Natl Acad Sci U S A. 117(25):14187-14193. 10.1073/pnas.1922903117. 2020 Jun 23
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for catalysis and substrate specificity of human ACAT1
Hongwu Qian#*, Xin Zhao#, Renhong Yan#, Xia Yao, Shuai Gao, Xue Sun, Ximing Du, Hongyuan Yang, Catherine C L Wong, Nieng Yan*
Nature. 581(7808):333-338. 10.1038/s41586-020-2290-0. 2020 May
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure and mechanism of human diacylglycerol O-acyltransferase 1
Lie Wang#, Hongwu Qian#, Yin Nian#, Yimo Han#, Zhenning Ren, Hanzhi Zhang, Liya Hu, B. V. Venkataram Prasad, Arthur Laganowsky, Nieng Yan*, Ming Zhou*
Nature. 581(7808):329-332. 10.1038/s41586-020-2280-2. 2020 May
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
High-yield monolayer graphene grids for near-atomic resolution cryoelectron microscopy
Yimo Han#*, Xiao Fan, Haozhe Wang, Fang Zhao, Christopher G Tully, Jing Kong, Nan Yao, Nieng Yan*
Proc Natl Acad Sci U S A. 117(2):1009-1014. 10.1073/pnas.1919114117. 2020 Jan 14
2019
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators
Ximin Chi#, Deshun Gong#*, Kang Ren, Gewei Zhou, Gaoxingyu Huang, Jianlin Lei, Qiang Zhou, Nieng Yan*
Proc Natl Acad Sci U S A. 116(51):25575-25582. 10.1073/pnas.1914451116. 2019 Dec 17
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Cryo-EM structures of apo and antagonist-bound human Cav3.1
Yanyu Zhao#, Gaoxingyu Huang#, Qiurong Wu#, Kun Wu#, Ruiqi Li, Jianlin Lei, Xiaojing Pan, Nieng Yan*
Nature. 576(7787):492-497. 10.1038/s41586-019-1801-3. 2019 Dec
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Modulation of cardiac ryanodine receptor 2 by calmodulin
Deshun Gong#*, Ximin Chi#, Jinhong Wei#, Gewei Zhou, Gaoxingyu Huang, Lin Zhang, Ruiwu Wang, Jianlin Lei, S.R. Wayne Chen*, Nieng Yan*
Nature. 572(7769): 347-351. 10.1038/s41586-019-1377-y. 2019 Aug
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular basis for ligand modulation of a mammalian voltage-gated Ca2+ channel
Yanyu Zhao#, Gaoxingyu Huang#, Jianping Wu#*, Qiurong Wu, Shuai Gao, Zhen Yan, Jianlin Lei, Nieng Yan*
Cell. 177(6):1495-1506. 10.1016/j.cell.2019.04.043. 2019 May 30
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
Hongwu Qian#, Pingping Cao#, Miaohui Hu, Shuai Gao, Nieng Yan*, Xin Gong*
Nat Commun. 10(1):2320. 10.1038/s41467-019-10234-9. 2019 May 24
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis
Ying Liu, Huifang Hu, Jia Wang, Qiang Zhou, Peng Wu, Nieng Yan, Hong-Wei Wang, Jia-Wei Wu, Linfeng Sun*
Protein Cell. 10(5):365-369. 10.1007/s13238-018-0576-x. 2019 May
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins
Huaizong Shen#, Dongliang Liu#, Kun Wu, Jianlin Lei, Nieng Yan*
Science.363(6433):1303-1308. 10.1126/science.aaw2493. 2019 Mar 22
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA
Xiaojing Pan#, Zhangqiang Li#, Xiaoshuang Huang#, Gaoxingyu Huang#, Shuai Gao, Huaizong Shen, Lei Liu, Jianlin Lei, Nieng Yan*
Science, 363(6433):1309-1313. 10.1126/science.aaw2999. 2019 Mar 22
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs
Xin Jiang#, Jianping Wu, Meng Ke, Shuo Zhang, Yafei Yuan, Jason Ye Lin, Nieng Yan*
Cell Discov. 5:14. 10.1038/s41421-019-0082-1. 2019 Mar 5
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
The shape of human squalene epoxidase expands the arsenal against cancer (invited preview)
Andrew J. Brown*, Ngee Kiat Chua, Nieng Yan
Nat Commun. 10(1):888. 10.1038/s41467-019-08866-y. 2019 Feb 21
2018
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Human SEIPIN Binds Anionic Phospholipids
Renhong Yan#, Hongwu Qian#*, Ivan Lukmantara, Mingming Gao, Ximing Du, Nieng Yan*, Hongyuan Yang*
Dev Cell. 47(2): 248-256. 10.1016/j.devcel.2018.09.010. 2018 Oct 22
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1
Xiaojing Pan#, Zhangqiang Li#, Qiang Zhou#, Huaizong Shen#, Kun Wu#, Xiaoshuang Huang, Jiaofeng Chen, Juanrong Zhang, Xuechen Zhu, Jianlin Lei, Wei Xiong, Haipeng Gong, Bailong Xiao, Nieng Yan*
Science. 362(6412): eaau2486. 10.1126/science.aau2486. 2018 Oct 19
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for the modulation of voltage-gated sodium channels by animal toxins
Huaizong Shen#, Zhangqiang Li#, Yan Jiang#, Xiaojing Pan#, Jianping Wu, Ben Cristofori-Armstrong, Jennifer J. Smith, Yanni K. Y. Chin, Jianlin Lei, Qiang Zhou*, Glenn F. King*, Nieng Yan*
Science. 362(6412): eaau2596. 10.1126/science.aau2596. 2018 Oct 19
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin
Deshun Gong#*, Ximin Chi#, Kang Ren#, Gaoxingyu Huang, Gewei Zhou, Nieng Yan, Jianlin Lei, Qiang Zhou*
Nat Commun. 9(1): 3623. 10.1038/s41467-018-06075-7. 2018 Sep 6
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for the recognition of Sonic Hedgehog by human Patched1
Xin Gong#, Hongwu Qian#, Pingping Cao#, Xin Zhao, Qiang Zhou, Jianlin Lei, Nieng Yan*
Science. 361(6402): eaas8935. 10.1126/science.aas8935. 2018 Aug 10
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Simulating the ion permeation and ion selection for a eukaryotic voltage-gated sodium channel NavPaS
Juanrong Zhang#, Wenzhi Mao#, Yanhui Ren#, Rui-Ning Sun, Nieng Yan*, Haipeng Gong*
Protein Cell. 9(6):580-585. 10.1007/s13238-018-0522-y. 2018 Jun
2017
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
A glimpse of membrane transport through structures - Advances in the structural biology of the GLUT glucose transporters
Nieng Yan*
J Mol Biol. 429(17):2710-2725. 10.1016/j.jmb.2017.07.009. 2017 Aug 18
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Dimeric structure of the uracil: proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters
Xinzhe Yu#, Guanghui Yang#*, Chuangye Yan, Javier L Baylon, Jing Jiang, He Fan, Guifeng Lu, Kazuya Hasegawa, Hideo Okumura, Tingliang Wang, Emad Tajkhorshid, Shuo Li, Nieng Yan*
Cell Res. 27(8):1020-1033. 10.1038/cr.2017.83. 2017 Aug
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the Nav1.4-β1 Complex from Electric Eel
Zhen Yan#, Qiang Zhou#, Lin Wang#, Jianping Wu#, Yanyu Zhao, Gaoxingyu Huang, Wei Peng, Huaizong Shen, Jianlin Lei, Nieng Yan*
Cell. 170(3):470-482.e11. 10.1016/j.cell.2017.06.039. 2017 Jul 27
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter
Meng Ke#, Yafei Yuan, Xin Jiang, Nieng Yan*, Haipeng Gong*
PLoS Comput Biol. 13(6):e1005603. 10.1371/journal.pcbi.1005603. 2017 Jun 15
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the Human Lipid Exporter ABCA1
Hongwu Qian#, Xin Zhao, Pingping Cao, Jianlin Lei, Nieng Yan*, Xin Gong#*
Cell. 169(7):1228-1239.e10. 10.1016/j.cell.2017.05.020. 2017 Jun 15
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure-based assessment of disease-related mutations in human voltage-gated sodium channels
Weiyun Huang#, Minhao Liu, S. Frank Yan*, Nieng Yan*
Protein Cell. 8(6):401-438. 10.1007/s13238-017-0372-z. 2017 Jun
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution
Huaizong Shen#, Qiang Zhou#, Xiaojing Pan#, Zhangqiang Li#, Jianping Wu#, Nieng Yan*
Science. 355(6328):eaal4326. 10.1126/science.aal4326. 2017 Mar 3
2016
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Xin Gong#, Hongwu Qian#, Wei Shao#, Jingxian Li, Jianping Wu, Jun-Jie Liu, Wenqi Li, Hong-Wei Wang, Peter Espenshade*, Nieng Yan*
Cell Res. 26(11):1197-1211. 10.1038/cr.2016.123. 2016 Nov
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation
Xin Jiang#, Irina Smirnova, Vladimir Kasho, Jianping Wu, Kunio Hirata, Meng Ke, Els Pardon, Jan Steyaert, Nieng Yan, H. Ronald Kaback*
Proc Natl Acad Sci U S A. 113(44):12420-12425. 10.1073/pnas.1615414113. 2016 Nov 1
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2
Wei Peng#, Huaizong Shen#, Jianping Wu#, Wenting Guo, Xiaojing Pan, Ruiwu Wang, S. R. Wayne Chen*, Nieng Yan*
Science. 354(6310):aah5324. 10.1126/science.aah5324. 2016 Oct 21
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution
Jianping Wu#, Zhen Yan#, Zhangqiang Li#, Xingyang Qian, Shan Lu, Mengqiu Dong, Qiang Zhou, Nieng Yan*
Nature. 537(7619):191-196. 10.1038/nature19321. 2016 Sep 8
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Xiao-Chen Bai#, Zhen Yan#*, Jianping Wu#, Zhangqiang Li, Nieng Yan*
Cell Res. 26(9):995-1006. 10.1038/cr.2016.89. 2016 Sep
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
Xin Gong#, Hongwu Qian#, Xinhui Zhou#, Jianping Wu#, Tao Wan#, Pingping Cao, Weiyun Huang, Xin Zhao, Xudong Wang, Peiyi Wang, Yi Shi, George F Gao, Qiang Zhou*, Nieng Yan*
Cell.165(6):1467-1478. 10.1016/j.cell.2016.05.022. 2016 Jun 2
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters
Dong Deng*, Nieng Yan*
Protein Sci. 25(3):546-58. 10.1002/pro.2858. 2016 Mar
2015
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the voltage-gated calcium channel Cav1.1 complex
Jianping Wu#, Zhen Yan#, Zhangqiang Li, Chuangye Yan, Shan Lu, Mengqiu Dong, Nieng Yan*
Science. 350(6267):aad2395. 10.1126/science.aad2395. 2015 Dec 18
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular basis of ligand recognition and transport by glucose transporters
Dong Deng#, Pengcheng Sun#, Chuangye Yan, Meng Ke, Xin Jiang, Lei Xiong, Wenlin Ren, Kunio Hirata, Masaki Yamamoto, Shilong Fan, Nieng Yan*
Nature. 526(7573):391-6. 10.1038/nature14655. 2015 Oct 15
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels
Ruobing Ren#, Xinhui Zhou#, Yuan He, Meng Ke, Jianping Wu, Xiaohui Liu, Chuangye Yan, Yixuan Wu, Xin Gong, Xiaoguang Lei, S. Frank Yan, Arun Radhakrishnan, Nieng Yan*
Science. 349(6244):187-91. 10.1126/science.aab1091. 2015 Jul 10
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition
Xin Gong#, Jingxian Li#, Wei Shao#, Jianping Wu, Hongwu Qian, Ruobing Ren, Peter Espenshade*, Nieng Yan*
Cell Res. 25(4):401-11. 10.1038/cr.2015.32. 2015 Apr
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Specific RNA recognition by designer pentatricopeptide repeat protein
Cuicui Shen#, Xiang Wang#, Yexing Liu, Quanxiu Li, Zhao Yang, Nieng Yan, Tingting Zou, Ping Yin*
Mol Plant. 8(4):667-70. 10.1016/j.molp.2015.01.001. 2015 Apr 8
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural biology of the major facilitator superfamily transporters
Nieng Yan*
Annu Rev Biophys. 2015:44:257-83. 10.1146/annurev-biophys-060414-033901. 2015
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution
Zhen Yan#, Xiao-chen Bai#, Chuangye Yan#, Jianping Wu, Zhangqiang Li, Tian Xie, Wei Peng, Chang-cheng Yin, Xueming Li, Sjors H. W. Scheres*, Yigong Shi* & Nieng Yan*
Nature. 517(7532):50-55. 10.1038/nature14063. 2015 Jan 1
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Hopes for the year ahead
Óscar Fernández-Capetillo, Nieng Yan, Jen Dionne, Danielle Bassett, Suchitra Sebastian, Christine Hendon, Hilke Schlichting, Monya Baker
Nature. 517(7532):111-3. 10.1038/nj7532-111a. 2015 Jan 1
2014
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Crystal structure of a bacterial homologue of SWEET transporters
Jing Wang#, Chuangye Yan, Yini Li, Kunio Hirata, Masaki Yamamoto, Nieng Yan*, Qi Hu*
Cell Res. 24(12):1486-9. 10.1038/cr.2014.144. 2014 Dec
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Examination of the Dimerization States of the Single-stranded RNA-recognition Protein PPR10
Quanxiu Li#, Chuangye Yan, Huisha Xu, Zheng Wang, Jiafu Long, Wenqi Li, Jianping Wu, Ping Yin*, Nieng Yan*
J Biol Chem. 289(45):31503-12. 10.1074/jbc.M114.575472. 2014 Nov 7
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
The recombinant expression systems for structure determination of eukaryotic membrane proteins
Yuan He#, Kan Wang, and Nieng Yan*
Protein Cell. 5(9):658-72. 10.1007/s13238-014-0086-4. 2014 Sep
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Crystal structure of the human glucose transporter GLUT1
Dong Deng#, Chao Xu#, Pengcheng Sun#, Jianping Wu#, Chuangye Yan, Mingxu Hu, Nieng Yan*
Nature. 510(7503):121-5. 10.1038/nature13306. 2014 Jun 5
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Identification and Characterization of ABA Receptors in Oryza sativa
Yuan He#, Qi Hao, Wenqi Li, Chuangye Yan, Nieng Yan*, Ping Yin*
PLoS One. 9(4):e95246. 10.1371/journal.pone.0095246. 2014 Apr 17
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Revisiting the TALE repeat
Dong Deng#, Chuangye Yan, Jianping Wu, Xiaojing Pan, Nieng Yan*
Protein Cell. 5(4):297-306. 10.1007/s13238-014-0035-2. 2014 Apr
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Functional architecture of MFS D-glucose transporters
M. Gregor Madej#, Linfeng Sun#, Nieng Yan*, H. Ronald Kaback*
Proc Natl Acad Sci U S A. 111(7):E719-27. 10.1073/pnas.1400336111. 2014 Feb 18
2013
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for the modular recognition of single-stranded RNA by PPR proteins
Ping Yin#, Quanxiu Li#, Chuangye Yan, Ying Liu, Junjie Liu, Feng Yu, Zheng Wang, Jiafu Long, Jianhua He, Hong-Wei Wang, Jiawei Wang, Jian-Kang Zhu, Yigong Shi, Nieng Yan*
Nature. 504(7478):168-71. 10.1038/nature12651. 2013 Dec 5
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13
Wenqi Li#, Li Wang#, Xinlei Sheng#, Chuangye Yan, Rui Zhou, Jing Hang, Ping Yin, Nieng Yan*
Cell Res. 23(12):1369-79. 10.1038/cr.2013.143. 2013 Dec
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural investigation of the proton-coupled secondary transporters
Nieng Yan*
Curr Opin Struct Biol. ;23(4):483-91. 10.1016/j.sbi.2013.04.011. 2013 Aug
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
The mechanism of Na+/K+ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation
Mengdie Xia#, Huihui Liu#, Yang Li#, Nieng Yan, Haipeng Gong*
Biophys J. 104(11):2401-9. 10.1016/j.bpj.2013.04.035. 2013 Jun 4
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Evolutionary mix-and-match with MFS transporters
M. Gregor Majej, Shangyu Dang, Nieng Yan, H. Ronald Kaback*
Proc Natl Acad Sci U S A. 110(15):5870-4. 10.1073/pnas.1303538110. 2013 Apr 9
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural advances for the major facilitator superfamily (MFS) transporters
Nieng Yan*
Trends Biochem Sci. 38(3):151-9. 10.1016/j.tibs.2013.01.003. 2013 Mar
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Analysis of the selectivity filter of the voltage-gated sodium channel NavRh
Xu Zhang#, Mengdie Xia#, Yang Li#, Huihui Liu#, Xin Jiang, Wenlin Ren, Jianping Wu, Paul DeCaen, Feng Yu, Sheng Huang, Jianhua He, David Clapham, Nieng Yan, Haipeng Gong*
Cell Res. 23(3):409-22. 10.1038/cr.2012.173. 2013 Mar
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
The conformational shifts of the voltage sensing domains between NavRh and NavAb
Xu Zhang#, Nieng Yan*
Cell Res. 23(3):444-7. 10.1038/cr.2012.158. 2013 Mar
2012
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Specific DNA-RNA hybrid recognition by TAL effectors
Ping Yin#, Dong Deng#, Chuangye Yan, Xiaojing Pan, Jianzhong Jeff Xi, Nieng Yan, Yigong Shi*
Cell Rep. 2(4):707-13. 10.1016/j.celrep.2012.09.001. 2012 Oct 25
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Crystal structure of a bacterial homologue of glucose transporters GLUT1-4
Linfeng Sun#, Xin Zeng#, Chuangye Yan, Xiuyun Sun, Xinqi Gong, Yu Rao, Nieng Yan*
Nature. 490(7420):361-6. 10.1038/nature11524. 2012 Oct 18
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Recognition of methlyated DNA by TAL effectors
Dong Deng#, Ping Yin#, Chuangye Yan, Xiaojing Pan, Xinqi Gong, Shiqian Qi, Tian Xie, Magdy Mahfouz, Jian-Kang Zhu, Nieng Yan*, Yigong Shi*
Cell Res. 22(10):1502-4. 10.1038/cr.2012.127. 2012 Oct
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy
Junichi Sugihara#, Linfeng Sun, Nieng Yan, H Ronald Kaback*
Proc Natl Acad Sci U S A. 109(37):14847-51. 10.1073/pnas.1213445109. 2012 Sep 11
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
Xu Zhang#, Wenlin Ren#, Paul DeCaen#, Chuangye Yan, Xiao Tao, Lin Tang, Jingjing Wang, Kazuya Hasegawa, Takashi Kumasaka, Jianhua He, Jiawei Wang, David E. Clapham, Nieng Yan*
Nature. 486(7401):130-4. 10.1038/nature11054. 2012 May 20
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural basis for the specific recognition of DNA by TAL effectors
Dong Deng#, Chuangye Yan#, Xiaojing Pan#, Magdy Mahfouz, Jiawei Wang, Jian-Kang Zhu, Yigong Shi*, Nieng Yan*
Science. 335(6069):720-3. 10.1126/science.1215670. 2012 Feb 5
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular mechanism for the inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by the protein phosphatase ABI1
Tian Xie#, Ruobing Ren#, Yuan-Yuan Zhang#, Yuxuan Pang, Chuangye Yan, Xinqi Gong, Yuan He, Wenqi Li, Di Miao, Qi Hao, Haiteng Deng, Zhixin Wang, Jia-Wei Wu*, Nieng Yan*
J Biol Chem. 287(1):794-802. 10.1074/jbc.M111.313106. 2012 Jan 2
2011
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
A Small-Molecule Screen Identifies L-Kynurenine as a Competitive Inhibitor of TAA1/TAR Activity in Ethylene-Directed Auxin Biosynthesis and Root Growth in Arabidopsis
Wenrong He#, Javier Brumos, Hongjiang Li, Yusi Ji, Meng Ke, Xinqi Gong, Qinglong Zeng, Wenyang Li, Xinyan Zhang, Fengying An, Xing Wen, Pengpeng Li, Jinfang Chu, Xiaohong Sun, Cunyu Yan, Nieng Yan, De-Yu Xie, Natasha Raikhel, Zhenbiao Yang, Anna N. Stepanova, Jose M. Alonso, Hongwei Guo*
Plant Cell. 23(11):3944-60. 10.1105/tpc.111.089029. 2011 Nov 22
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
The molecular Basis of ABA-independent inhibition of PP2Cs by a subclass of PYL proteins
Qi Hao#, Ping Yin#, Wenqi Li#, Li Wang Chuangye Yan, Zhaohu Lin, Jim Zhen Wu, Jiawei Wang, S. Frank Yan, Nieng Yan*
Mol Cell. 42(5):662-72. 10.1016/j.molcel.2011.05.011. 2011 Jun 10
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure and mechanism of the uracil transporter UraA
Feiran Lu#, Shuo Li#, Yang Jiang, Jing Jiang, He Fan, Guifeng Lu, Dong Deng, Shangyu Dang, Xu Zhang, Jiawei Wang, Nieng Yan*
Nature. 472(7342):243-6. 10.1038/nature09885. 2011 Apr 14
2010
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
The structure of a fucose transporter in an outward-open conformation
Shangyu Dang, Linfeng Sun#, Feiran Lu#, Jiawei Wang*, Nieng Yan*
Nature. 467(7316):734-8. 10.1038/nature09406. 2010 Oct 7
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Single amino acid alteration between isoleucine and valine determinates the pyrabactin selectivity between PYL1 and PYL2
Xiaoqiu Yuan#, Ping Yin#, Qi Hao#, Chuangye Yan, Wenqi Li, Jiawei Wang, Nieng Yan*
J Biol Chem. 285(37):28953-8. 10.1074/jbc.M110.160192. 2010 Sep 10
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Functional mechanism of the Abscisic Acid agonist pyrabactin
Qi Hao#, Ping Yin#, Chuangye Yan#, Xiaoqiu Yuan, Chuangye Yan, Wenqi Li, Jiawei Wang, Nieng Yan*
J Biol Chem. 285(37):28946-52. 10.1074/jbc.M110.149005. 2010 Sep 10
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4
Shiqian Qi#, Yuxun Pang#, Qi Hu, Qun Liu, Hua Li, Yulian Zhou, Tianxi He, Qionglin Liang, Yexing Liu, Xiaoqiu Yuan, Guoan Luo, Huilin Li, Jiawei Wang, Nieng Yan*, Yigong Shi*
Cell. 141(3):446-57. 10.1016/j.cell.2010.03.017. 2010 Apr 30
2009
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural insights into the mechanism of abscisic acid signaling by PYL proteins
Ping Yin#, He Fan#, Qi Hao#, Xiaoqiu Yuan#, Di Wu, Yuxuan Pang, Chuangye Yan, Wenqi Li, Jiawei Wang, Nieng Yan*
Nat Struct Mol Biol. 16(12):1230-6. 10.1038/nsmb.1730. 2009 Dec
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel
Yi Wang#, Yongjian Huang#, Jiawei Wang#, Chao Cheng, Weijiao Huang, Peilong Lu, Ya-Nan Xu, Pengye Wang, Nieng Yan*, Yigong Shi*
Nature. 462(7272):467-72. 10.1038/nature08610. 2009 Nov 26
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Caenorhabditis Elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells
Xin Geng#, QH Zhou#, E Kage-Nakadai, Yigong Shi, Nieng Yan, Shohei Mitani, Ding Xue*
Cell Death Differ. 16(10):1385-94. 10.1038/cdd.2009.88. 2009 Oct
2007
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of a Site-2 Protease Family Intramembrane Metalloprotease
Liang Feng#, Hanchi Yan#, Zhuoru Wu#, Nieng Yan, Zhe Wang, Philip D. Jeffrey, Yigong Shi*
Science. 318(5856):1608-12. 10.1126/science.1150755. 2007 Dec 7
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Allosteric activation of a bacterial stress sensor
Nieng Yan*, Yigong Shi*
Cell. 131(3):441-3. 10.1016/j.cell.2007.10.021. 2007 Nov 2
2006
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry
Zhuoru Wu#, Nieng Yan#, Liang Feng#, Adam Oberstein, Hanchi Yan, Rosanna P Baker, Lichuan Gu, Philip D Jeffrey, Sinisa Urban, Yigong Shi*
Nat Struct Mol Biol. 13(12):1084-91. 10.1038/nsmb1179. 2006 Dec
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in C. elegans
Chonglin Yang#, Nieng Yan, Jay Parish, Xiaochen Wang, Yigong Shi, Ding Xue*
J Biol Chem. 281(14):9137-44. 10.1074/jbc.M511742200. 2006 Apr 7
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure and activation mechanism of the Drosophila initiator caspase Dronc*
Nieng Yan#, Jun R. Huh, Vrigil Schirf, Borries Demeler, Bruce A. Hay, Yigong Shi*
J Biol Chem. 281(13):8667-74. 10.1074/jbc.M513232200. 2006 Mar 31
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
2:1 Stoichiometry of the CED-4-CED-9 Complex and the Tetrameric CED-4: Insights into the Regulation of CED-3 Activation
Nieng Yan#, Yanhui Xu, Yigong Shi*
Cell Cycle. 5(1):31-4. 10.4161/cc.5.1.2263. 2006 Jan 18
2005
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the CED-4/CED-9 complex provides insights into programmed cell death in C. elegans
Nieng Yan#, Jijie Chai, Eui Seung Lee, Lichuan Gu, Qun Liu, Jiaqing He, Jia-Wei Wu, David Kokel, Huilin Li, Quan Hao, Ding Xue, Yigong Shi*
Nature. 437(7060):831-7. 10.1038/nature04002. 2005 Oct 6
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Mechanisms of Apoptosis through Structural Biology
Nieng Yan*, Yigong Shi*
Annu Rev Cell Dev Biol. 2005:21:35-56. 10.1146/annurev.cellbio.21.012704.131040. 2005 Oct 16
2004
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular Mechanism of AHSP-Mediated Stabilization of α-Hemoglobin
Liang Feng#, David A. Gell#, Suiping Zhou#, Lichuan Gu, Yi Kong, Jianqing Li, Min Hu, Nieng Yan, Christopher Lee, Anne M. Rich, Robert S. Armstrong, Peter A. Lay, Andrew J. Gow, Mitchell J. Weiss*, Joel P. Mackay*, Yigong Shi*
Cell. 119(5):629-40. 10.1016/j.cell.2004.11.025. 2004 Nov 24
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Direct Binding of DNA by Tumor Suppressor Menin
Ping La#, Albert C. Silva, Zhaoyuan Hou, Haoren Wang, Robert W. Schnepp, Nieng Yan, Yigong Shi, Xianxin Hua*
J Biol Chem. 279(47):49045-54. 10.1074/jbc.M409358200. 2004 Nov 19
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4
Nieng Yan#, Lichuan Gu#, David Kokel#, Jijie Chai, Wenyu Li, Aidong Han, Lin Chen, Ding Xue, Yigong Shi*
Mol Cell. 15(6):999-1006. 10.1016/j.molcel.2004.08.022. 2004 Sep 24
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide: Implications for Signaling
Eric N. Shiozaki#, Lichuan Gu, Nieng Yan, and Yigong Shi*
Mol Cell. 14(3):405-12. 10.1016/s1097-2765(04)00238-2. 2004 May 7
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid, and Grim
Nieng Yan#, Jia-Wei Wu, Jun R. Huh, Jijie Chai, Wenyu Li, Bruce A. Hay, Yigong Shi*
Nat Struct Mol Biol. 11(5):420-8. 10.1038/nsmb764. 2004 May
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Multiple apoptotic caspase cascades are required in non-apoptotic roles for Drosophila spermatid individualization
Jun R. Huh#, Stephanie Y. Vernooy, Hong Yu, Nieng Yan, Yigong Shi, Ming Guo, Bruce A. Hay*
PLoS Biol. 2(1):E15. 10.1371/journal.pbio.0020015. 2004 Jan
2003
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Histone H1.2 as a trigger for apoptosis
Nieng Yan, Yigong Shi*
Nat Struct Biol. 10(12):983-5. 10.1038/nsb1203-983. 2003 Dec
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Molecular mechanism of Reaper/Grim/Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
Jijie Chai#, Nieng Yan#, Jun R. Huh, Jia-Wei Wu, Wenyu Li, Bruce A. Hay, Yigong Shi*
Nat Struct Biol. 10(11):892-8. 10.1038/nsb989. 2003 Nov
“ # ” indicates co-first authors; “ * ” indicates corresponding authors.
Features of a Smad3 MH1-DNA complex: Roles of water and zinc in DNA binding
Jijie Chai#, Jia-Wei Wu, Nieng Yan, Joan Massagué, Nikola P. Pavletich, Yigong Shi*
J Biol Chem. 278(22):20327-31. 10.1074/jbc.C300134200. 2003 May 30
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